Fragile X syndrome is the nost cotnntonform offanilial nental retardation and is associated with afragile site at the end of long arn chrotnosonre X. Whilst screening for chrontosoual abnornalities in nentally retarded nales attending special school, we have identified thefirst fanily with afragile x syndrone, to be reported in Indonesia. ph1,sis.1 exatnination,fatnill, l1isg6r, as well as cyto9enetic and DNA studies identified tv,o pheno4,pically abnonnal brorhers who were fragile X posirive 3% (Dn) and 4% (pr). Their sister (Cl) and utother were pheno\,pically and intellectually nornal but were cytogenetically positive for fragile X (6% in the sister and 3% in lhe nother). Molecular analysis confirnted that both broîhers were afected and that their sister and tnother were carriers. Signs and symptoms of fragile X syndrome Physical abnormalities Symptoms of fragile X syndrome can be seen and recognized from the physical look of the sufferer. Usually the people with a spe...